This textbook was written to provide a comprehensive, integrated, and practical reference for clinical geneticists, cytogeneticists, clinical laboratory scientists, genetic counselors, and trainees working with chromosomal microarray analysis. It bridges the conceptual, mathematical, and clinical dimensions of the field beginning with the molecular biology and laboratory workflow of microarray technology, progressing through genomic architecture, mathematical foundations, and variant classification frameworks, and culminating in comprehensive coverage of recognized genomic disorders and clinical indications.